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1. This tiny website was prepared by the
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2. Some parts of this page might seem to be
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What is Anisomycin
Anisomycin
is a bacterial antibiotic isolated from Streptomyces
griseolus, water and solvents soluble, a low molecular
weight of 265.
Anisomycin inhibits
eukaryotic protein synthesis, by binding to 60S
ribosomal subunits and blocking peptide bond
formation, so stopping elongation and
causing polysome stagnation. The outcome of that, is
chromosomal DNA degradation and apoptosis.
Anisomycin
was first reported in 1954 by
Sobin at al. [1]
Not before 1967 did anyone reported the ability of
Anisomycin to inhibit protein synthesis. [2]
The first report connecting Anisomycin and amnesia
appeared in 1974 [3]
In 1975-1977 several works appeared dealing with
Anisomycin inhibiting cellular and mitochondrial protein
synthesis, and three dealt with memory phenomena: (4),
(5), (6)
Several works were done on inhibition of
acetyl cholinesterase by Anisomycin.
Eighties: as monitored in the terms of number of
papers in the decade
|
Antiparasitic |
2 |
|
Protein synthesis |
2 |
|
Memory, CNS development and functioning |
30 |
|
Miscellaneous effects, particularly on mamalian
sexual endocrinology |
4 |
|
General antineoplastic |
0 |
|
Miscellaneous chemistry, derivates |
1 |
|
Protein kinases, cell sygnalling, apoptosis |
0 |
Nineties: as monitored in the terms of number of
papers in the decade
|
Antiparasitic |
2 |
|
Protein synthesis |
2 |
|
Memory, CNS development and functioning |
5 |
|
General drug related |
6 |
|
General antineoplastic |
0 |
|
Miscellaneous chemistry, derivates |
0 |
|
Protein kinases, cell signaling, apoptosis |
11 |
Current trends: as monitored in the terms of
number of papers since 2000
|
Memory, CNS development and functioning |
17 |
|
Miscellaneous chemistry, derivates, general
antineoplastic |
7 |
|
Protein kinases, cell sygnalling, apoptosis |
21 |
|
|
|
(1)
Sobin, B. A. et al. (1954) J. Am. Chem. Soc.
76, 4053 |
|
(2)
J Biol Chem. 1967 Jul 10;242(13):3226-33.
Inhibitors of protein biosynthesis.
II. Mode of action of Anisomycin. |
(3)
Flood JF, Rosenzweig MR, Bennett EL, Orme AE. :
Comparison of the effects of anisomycin on
memory across six strains of mice.
Behav Biol. 1974 Feb;10(2):147-60. |
|
(4)
Bull R, Ferrera E, Orrego F.
Effects of anisomycin on brain protein synthesis and passive
avoidance learning in newborn chicks.
J Neurobiol.
1976 Jan;7(1):37-49 |
|
(5)
Moss DE, Fahrney D. Anisomycin,
acetoxycycloheximide, cycloheximide, and puromycin as
inhibitors of rat brain acetylcholinesterase in vitro.
J Neurochem.
1976 Jun;26(6):1155-7. |
|
(6)
Flood JF, Bennett EL, Orme AE, Rosenzweig MR, Jarvik ME.
Memory: modification of anisomycin-induced
amnesia by stimulants and depressants.
Science.
1978 Jan 20;199(4326):324-6. |
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